TVA Medical | Unmet Need

Hemodialysis Patients Need a Better Solution

Vascular access is the “lifeline” for hemodialysis patients. Options for access include central venous catheters, AV grafts, and AV fistulas. Regardless of the modality, current access options remain limited.

 

Vascular access is the leading cause of hospitalizations and morbidity in patients with end stage renal disease. Surgical fistulas are the preferred vascular access with lower mortality rates, less infections and lower cost of dialysis delivery, however they are not a perfect solution.

UNMET NEED
ANNUAL DIALYSIS COSTS
~ AVF Annual Costs Are Significantly Lower ~
SURGICAL AVF CHALLENGES
~ Maturation and Intervention Rates, Thrombosis ~

1. Woo K., et al. Influence of Vascular Access Type on Sex and Ethnicity-Related Mortality in Hemodialysis-Dependent Patients. Perm J 2012 Spring;16(2):4-9 

2. USRDS Annual Report 2012. 

3. US Renal Data System. USRDS 2010 Annual Report 

4. Dember LM, Beck GJ, Allon M, et al; Dialysis Access Consortium Study Group. Effect of clopidogrel on early
failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial. JAMA. 2008;299:2164-2171. 

5. Al-Jaishi AA, Oliver MJ, Thomas SM, et al. Patency rates of the arteriovenous fistula for hemodialysis: a systematic review and meta-analysis. Am J Kidney Dis. 2014;63:464-478. 

6. Swindlehurst N, Swindlehurst A, Lumgair H, Rebollo Mesa I, Mamode N, Cacciola R, Macdougall I. Vascular Access for Hemodialysis in the Elderly. J Vasc Surg 2011;53:1039-1043. 

7. Huijbregts HJ, Bots ML, Wittens CH, Schrama YC, Moll FL, Blankestijn PJ; CIMINO study group. Hemodialysis arteriovenous fistula patency revisited: results of a prospective, multicenter initiative. Clin J Am Soc Nephrol. 2008;3:714-719. 

8. Peterson WJ, Barker J, Allon M. Disparities in Fistula Maturation Persist Despite Preoperative Vascular Mapping. Clin J Am Soc Nephol. 2008; 3:437-441. 

9. Kimball, et al. Efficiency of the kidney disease outcomes quality initiative guidelines for preemptive vascular access in an academic setting. Journal of Vascular Surgery. Vol 54, No 3. 2011 

10. Falk, A.M. Maintenance and Salvage of Arteriovenous Fistulas. J Vasc Interv Radiol 2006; 17:807–813

11. Stolic R. Most Important Chronic Complications of Arteriovenous Fistulas for Hemodialysis. Med Princ Pract. 2012